2026 NFL Odds Week 2: Lines, Spreads, Results For All 16 Games

Week 2 is in our sights, headlined by a Thursday night clash between the Lions and the Bills in Buffalo. Here are the lines for every Week 2 matchup at bet365 Sportsbook as of Sept. 14. This page may contain affiliate links to legal sports betting partners. If you sign up or place a wager, FOX Sports may be compensated. Read more about Sports Betting on FOX Sports. Lions @ Bills Spread: Bills -3.5Moneyline: Bills -185, Lions +155O/U: 53.5 Panthers @ Falcons Spread: Falcons -1.5Moneyline: Falcons -120, Panthers +100O/U: 44.5 Bengals @ Texans Spread: Texans -2.5Moneyline: Texans -140, Bengals +120O/U: 47.5 Browns @ Buccaneers Spread: Bucs -8.5Moneyline: Bucs -425, Browns +325O/U: 40.5 Packers @ Jets Spread: Packers -4.5Moneyline: Packers -220, Jets +180O/U: 45.5 Vikings @ Bears Spread: Bears -5.5Moneyline: Bears -250, Vikings +205O/U: 48.5 Saints @ Ravens Spread: Ravens -8.5Moneyline: Ravens -425, Saints +325O/U: 47.5 Eagles @ Titans Spread: Eagles -7Moneyline: Eagles -340, Titans +270O/U: 39.5 Steelers @ Patriots Spread: Patriots -5.5Moneyline: Patriots -240, Steelers +195O/U: 42.5 Jaguars @ Broncos Spread: Broncos -2.5Moneyline: Broncos -140, Jaguars +120O/U: 43.5 Raiders @ Chargers Spread: Chargers -7.5Moneyline: Chargers -330, Raiders +265O/U: 44.5 Dolphins @ 49ers Spread: 49ers -12.5Moneyline: 49ers -950, Dolphins +625O/U: 46.5 Commanders @ Cowboys Spread: TBDMoneyline: TBDO/U: TBD Seahawks @ Cardinals Spread: Seahawks -4.5Moneyline: Seahawks -230, Cardinals +190O/U: 41.5 Colts @ Chiefs Spread: Chiefs -6.5Moneyline: Chiefs -290, Colts +235O/U: 48.5 Giants @ Rams Spread: TBDMoneyline: TBDO/U: TBD